Custom NEXTFLEX® Panels
Custom panels can be designed to genes, breakpoints and CNVs. The design can be augmented with amplicons for pseudogenes, fuzzy breakpoints and short repeat expansions.
Example Custom NEXTFLEX® Extended Carrier Panel
Contains redundantly tiled Molecular Inversion Probes (MIPs) for 1722 targets. Targets include:
- Complete coding exonic sequences of 89 genes, at least 15 bases of exon-adjacent intronic sequences, and Clinvar database-specified pathogenic/likely pathogenic mutations located in introns or promoters of these genes,
- Mutation hotspots in additional 16 genes,
- Breakpoint probes for nine large deletions and one duplication,
- Selected mutations in 11 genes relevant to infertility conditions and microdeletions in three Azoospermia Factor regions of chromosome Y.