Increase miRNA sequencing reads NEXTFLEX® tRNA/YRNA blockers into your small RNA-sequencing workflow. These blockers reduce the number of YRNA and tRNA fragments in small RNA libraries, increasing the miRNA reads. tRNA and YRNA fragments are abundant in sample types like plasma and serum. For researchers who are primarily interested in miRNAs and other small RNAs, reads lost to the abundant tRNA and YRNA fragments leads to a lower number of reads mapping to their RNA species of interest. Coupling the NEXTFLEX® tRNA/YRNA blockers with the NEXTFLEX® small RNA sequencing chemistry and data security of UDIs allows users to maximize the patented and patent-pending technology for ligase-associated bias reduction, which enables superior miRNA discovery for the same sequencing depth.