BIOTHERAPEUTICS & ANTIBODY DISCOVERY AUTOMATION SOLUTIONS
Automating Drug Discovery Workflows
Drug discovery workflows require tools and technologies that can support a broad range of current and future applications including multiple microplate formats, liquid transfer volumes, and detection based read-out methods. The explorer™ G3 integrated HTS workstations are designed to fulfill these diverse needs.
Reverse Transcription & PCR
This explorer™ G3 workstation has been configured to automated cDNA synthesis and PCR in preparation for cloning
Configuration Requirements:
- JANUS® G3 Expanded platform with 8-tip pipetting arm, gripper integration platform and INHECO® on-deck thermocycler
- Integrated Roche® LightCycler® LC480 qPCR instrument
- Integrated KBioSystem® WASP™ Plate sealer
- Enclosure with UV light option
- plate::works™ scheduling software
Cloning & Transfection into E. coli; Plasmid Extraction using Macherey-Nagel NucloSpin® Kit
This explorer™ G3 workstation has been configured to automate cloning, transfection, and extraction of plasmid DNA.
Configuration Requirements:
- JANUS® G3 Expanded platform with 8-tip and MDT(96) pipetting arm and gripper integration platform
- Integrated Victor® Nivo™ Multimode plate reader
- Integrated Cytomat™ 2C-LiN Plate incubator
- Integrated Liconic® LPX110™ Plate hotel
- Integrated Agilent® Technologies centrifuge
- Enclosure
- plate::works™ scheduling software
Clone Selection & Picking
This explorer™ G3 workstation was configured to automate expression profiling, mAb selection (hit picking) based on target binding data, and results from FACS.
Configuration Requirements
- Integrated JANUS® G3 Mini 8-tip liquid handling workstation with on deck plate::tiler™ and 2x PlateStak™ Labware stackers
- Integrated FORTEBIO® Octet® RED96 system
- Integrated Guava® easyCyte™ 5 flow cytometer
- Random access storage racks
- Lid handler
- Laser barcode reader for sample tracking
- plate::works™ scheduling software
HT Cloning, Transfection, and Screening
This explorer™ G3 workstation was configured to automate cloning, transfection, and screening in multiple parallel running experiments.
Configuration Requirements:
- Integrated JANUS® G3 Standard 8-tip liquid handling workstations with PlateStak™ labware stacker
- Integrated EnSight™ multimode reader
- Integrated KBioSystem® K6-3 colony picker
- Integrated KBioSystem® WASP™ sealer
- Integrate Analytik Jena®/Biometra® TRobot 96 thermocycler
- Integrated Agilent® Technologies centrifuge
- Integrated Brooks® XPeel® automated microplate peeler
- 8x INHECO® MP incubator
- Random access storage racks
- Laser barcode reader for sample tracking
- System enclosure with HEPA filter
- plate::works™ scheduling software
High-Throughput enzyme stability and activity testing, bacteria culturing, colony picking
This explorer™ G3 workstation was configured to automate the picking and cultivation of bacteria and yeast colonies and to test for activity.
Configuration Requirements:
- Integrated JANUS® G3 Mini 8-tip and JANUS® G3 Mini MDT liquid handling workstations
- Integrated EnVison® Multimode reader
- Integrated KBioSystem® K6-3 colony picker
- Integrated Hettich® Rotata centrifuge
- Integrated Liconic® STX44 incubator with shaking option
- Integrated Brooks® Xpeel® plate seal remover
- Integrated Agilent® Technologies PlateLoc™ sealer
- Integrated Scinomix® Sci-Print MP barcode labeler
- Random access storage racks
- Lid handler
- Laser barcode reader for sample tracking
- System enclosure with HEPA Filter
- plate::works™ scheduling software