BIOTHERAPEUTICS & ANTIBODY DISCOVERY AUTOMATION SOLUTIONS

Automating Drug Discovery Workflows

Drug discovery workflows require tools and technologies that can support a broad range of current and future applications including multiple microplate formats, liquid transfer volumes, and detection based read-out methods. The explorer G3 integrated HTS workstations are designed to fulfill these diverse needs.

Lab workstation module

Reverse Transcription & PCR

This explorer™ G3 workstation has been configured to automated cDNA synthesis and PCR in preparation for cloning

Configuration Requirements:

  • JANUS® G3 Expanded platform with 8-tip pipetting arm, gripper integration platform and INHECO® on-deck thermocycler
  • Integrated Roche® LightCycler® LC480 qPCR instrument
  • Integrated KBioSystem® WASP™ Plate sealer
  • Enclosure with UV light option
  • plate::works™ scheduling software
Lab workstation module

Cloning & Transfection into E. coli;  Plasmid Extraction using Macherey-Nagel NucloSpin® Kit

This explorer™ G3 workstation has been configured to automate cloning, transfection, and extraction of plasmid DNA.

Configuration Requirements:

  • JANUS® G3 Expanded platform with 8-tip and MDT(96) pipetting arm and gripper integration platform
  • Integrated Victor® Nivo Multimode plate reader
  • Integrated  Cytomat 2C-LiN Plate incubator
  • Integrated Liconic® LPX110 Plate hotel
  • Integrated Agilent® Technologies centrifuge
  • Enclosure
  • plate::works™ scheduling software
Lab workstation module

Clone Selection & Picking

This explorer™ G3 workstation was configured to automate expression profiling, mAb selection (hit picking) based on target binding data, and results from FACS.

Configuration Requirements

  • Integrated JANUS® G3 Mini 8-tip liquid handling workstation with on deck plate::tiler™ and 2x PlateStak™ Labware stackers
  • Integrated  FORTEBIO® Octet® RED96 system
  • Integrated Guava® easyCyte™ 5 flow cytometer
  • Random access storage racks
  • Lid handler
  • Laser barcode reader for sample tracking
  • plate::works™ scheduling software
Lab workstation module

HT Cloning, Transfection, and  Screening

This explorer™ G3 workstation was configured to automate cloning, transfection, and screening in multiple parallel running experiments.

Configuration Requirements:

  • Integrated JANUS® G3 Standard 8-tip liquid handling workstations with PlateStak™ labware stacker
  • Integrated  EnSight™ multimode reader
  • Integrated KBioSystem® K6-3 colony picker
  • Integrated KBioSystem® WASP™ sealer
  • Integrate Analytik Jena®/Biometra® TRobot 96 thermocycler
  • Integrated Agilent® Technologies centrifuge
  • Integrated Brooks® XPeel® automated microplate peeler
  • 8x INHECO® MP incubator
  • Random access storage racks
  • Laser barcode reader for sample tracking
  • System enclosure with HEPA filter
  • plate::works™ scheduling software
Lab workstation module

High-Throughput enzyme stability and activity testing, bacteria culturing, colony picking

This explorer™ G3 workstation was configured to automate the picking and cultivation of bacteria and yeast colonies and to test for activity.

Configuration Requirements:

  • Integrated JANUS® G3 Mini 8-tip and JANUS® G3 Mini MDT liquid handling workstations
  • Integrated  EnVison® Multimode reader
  • Integrated KBioSystem® K6-3 colony picker
  • Integrated Hettich® Rotata centrifuge
  • Integrated Liconic® STX44 incubator with shaking option
  • Integrated Brooks® Xpeel® plate seal remover  
  • Integrated Agilent® Technologies PlateLoc™ sealer
  • Integrated Scinomix® Sci-Print MP barcode labeler
  • Random access storage racks
  • Lid handler
  • Laser barcode reader for sample tracking
  • System enclosure with HEPA Filter
  • plate::works™ scheduling software