LabChip GXII Touch Protein Characterization System2019-06-19T17:25:36+00:00

IMPROVE THE ACCURACY OF YOUR AUTOMATED
PROTEIN ANALYSIS

LabChip® GXII Touch Protein Characterization System

The LabChip® GXII Touch protein characterization system provides the complete solution for reproducible quantitation, molecular weight sizing and percent purity analysis of protein samples. Leveraging microfluidic electrophoretic separation technology, the LabChip GXII Touch system enables rapid characterization with minimal sample preparation setup and sample input volume.

Versatile Instrument for Protein Analysis & Quantitation

  • Multiple assays available for quantification, molecular weight sizing, purity, charge variants and glycan analysis. With our pre-verified assays, there is no (or little) method development needed.
  • Rapidly determine the molecular weight, concentration and purity of every protein within your sample
  • Optimal for all throughput needs, with run cherry-picking to 96-well and 384-well high-throughput compatibility
  • Accelerate design space parameters with protein sample analysis from Quality of Design (QbD) and Design and of Experiment (DoE) studies
  • Instrument is applicable throughout the workflow, whether upstream in R&D through Process Development down to final Quality Control.
  • Intuitive touch screen interface with comprehensive analysis using LabChip® GX software enabling “True high-throughput analytics.” Analyze results electropherogram, tabular and virtual gel formats

The platform supports multiple assays for characterizing proteins in reduced and non-reduced samples including:

  • Analyze critical quality attributes in as few as 42 seconds:
  • Titer (concentration and sizing)
  • Purity assessment
  • Aggregation (covalently linked)
  • Stability (degradation / fragmentation analysis)
  • N-Glycan profiling
  • mAb Charge variant / charge heterogeneity
  • mAb impurity analysis (detect minor impurities)

Independent Analysis of LabChip® GXII Touch protein characterization system and assays for DoE development to assess critical parameters that assess mAb purity

Smith, M. T., Zhang, S., Adams, T., Dipaolo, B., & Dally, J. (2017). Establishment and validation of a microfluidic capillary gel electrophoresis platform method for purity analysis of therapeutic monoclonal antibodies. Electrophoresis,38(9-10), 1353-1365. doi:10.1002/elps.201600519

21CFR Part 11 Compatible Software is available with the LabChip® GXII Touch protein characterization system

To assist in your compliance planning, LabChip® GxP Security Software is available which allows the LabChip® GXII Touch protein characterization system to run in an environment consistent with CFR21 Part 11 compliance and validation. This includes access security, data security and verification, and a complete set of audit logging functionality. Please contact your local PerkinElmer representative for more information.

Dimensions
Height69 cm | 27 in
Width51 cm | 20 in
Depth49 cm | 19.5 in
For research use only. Not for use in diagnostic procedures.
Dimensions:
Height: 69 cm | 27 in
Width: 51 cm | 20 in
Depth: 49 cm | 19.5 in

Windows 10-compatible software

Accurate Sizing, Quantification and Quality Control of Proteins

Cao, J., Perez-Pinera, P., Lowenhaupt, K., Wu, M., Purcell, O., Fuente-Nunez, C. D., & Lu, T. K. (2018). Versatile and on-demand biologics co-production in yeast. Nature Communications, 9(1). doi:10.1038/s41467-017-02587-w.

Reardon, H. T., Herbst, R. A., Henry, C. L., Herbst, D. M., Ngo, N., Cisar, J. S., . . . O’Neill, G. P. (2019). Quantification of In Vivo Target Engagement Using Microfluidic Activity-Based Protein Profiling. SLAS TECHNOLOGY: Translating Life Sciences Innovation,247263031985230. doi:10.1177/2472630319852303

Regula, J. T., Imhof-Jung, S., Mølhøj, M., Benz, J., Ehler, A., Bujotzek, A., . . . Klein, C. (2018). Variable heavy–variable light domain and Fab-arm CrossMabs with charged residue exchanges to enforce correct light chain assembly. Protein Engineering, Design and Selection,31(7-8), 289-299. doi:10.1093/protein/gzy021.

Smith, M. T., Zhang, S., Adams, T., Dipaolo, B., & Dally, J. (2017). Establishment and validation of a microfluidic capillary gel electrophoresis platform method for purity analysis of therapeutic monoclonal antibodies. Electrophoresis,38(9-10), 1353-1365. doi:10.1002/elps.201600519

Smith, M. T., Zhang, S., Adams, T., Dipaolo, B., & Dally, J. (2017). Establishment and validation of a microfluidic capillary gel electrophoresis platform method for purity analysis of therapeutic monoclonal antibodies. Electrophoresis,38(9-10), 1353-1365. doi:10.1002/elps.201600519.

Weng, Y., Ishino, T., Sievers, A., Talukdar, S., Chabot, J. R., Tam, A., . . . Lin, L. (2018). Glyco-engineered Long Acting FGF21 Variant with Optimal Pharmaceutical and Pharmacokinetic Properties to Enable Weekly to Twice Monthly Subcutaneous Dosing. Scientific Reports, 8(1). doi:10.1038/s41598-018-22456-w.