ENABLING BIOBANKS TO EMPOWER RESEARCH
Biobanking with PerkinElmer
Facing an ever-increasing demand, biobanks empower clinical, pharmaceutical, and basic research to increase our understanding of complex diseases by delivering the right resources, to the right researcher, at the right time. PerkinElmer enables biobanks to serve their customers’ needs by developing complete, validated workflow solutions providing high quality nucleic acid extraction, automation with flexible throughput, and sample process traceability ensuring the accurate identification of samples.
Uniquely Positioned to Empower Research
PerkinElmer is uniquely positioned to enable biobanks to empower research with high quality nucleic acid extraction and QC and analysis solutions, modular and scalable automation, and sole source integration, delivering the flexibility biobanks need to meet their changing demands.
For research use only. Not for use in diagnostic procedures.
NUCLEIC ACID EXTRACTION EXPERTISE
Input Agnostic Nucleic Acid Extraction
Since the samples collected by biorepositories can be extremely diverse, the ability to isolate nucleic acids from an extensive range of sample types and volumes is critical. With the ability to extract nucleic acids from 10 µL to 10 mL of input samples, PerkinElmer’s chemagic™ reagents and automation solutions are agnostic for both starting materials and type of nucleic acid extracted(1 – 10).
High Quality Nucleic Acids
Nucleic acid quality is of major importance when conducting molecular analysis since factors causing degradation, presence of impurities, and enzymatic inhibitors, and long-term storage can have a significant impact on the quality of data. PerkinElmer’s chemagen™ technology addresses the challenges associated with extraction while offering high recovery of clean nucleic acids suitable for long-term storage and a variety of demanding downstream applications. The shaking and centrifugation steps typically resulting in nucleic acid denaturation and fragmentation are avoided with chemagen™ technology. This automated magnetic separation procedure uses chemagen™ M-PVA magnetic beads to isolate and purify nucleic acids from human sample material. The beads have a high affinity for nucleic acids and low inhibitor binding, resulting in ultra-pure DNA and RNA. chemagen™ technology features magnetizable rotating rods, combining the transfer and suspension of magnetic beads to extract DNA, preventing further fragmentation. There are optimized protocols available for high molecular weight DNA as well as for cell free DNA (cfDNA). The nucleic acids isolated are compatible with a wide range of downstream applications including NGS, PCR, and MLPA(1 – 10).
chemagic™ 360 INSTRUMENT
With the ability to isolate nucleic acids from 96 to 4,000 samples per day and the flexibility to isolate DNA or RNA from any other human sample type, the chemagic™ 360 Instrument is designed to meet labs high-throughput nucleic acid isolation needs.
chemagic™ Prime INSTRUMENT
The chemagic™ Prime instrument offers high throughput primary sample transfer along with nucleic acid isolation for high throughput labs, isolating and processing nucleic acids from 96 to 1,000 samples per day per day.
NUCLEIC ACID QUALITY ASSESSMENT
& QUANTITATION EXPERTISE
Eliminate your nucleic acid QC and quantitation bottlenecks with seamless analysis solutions validated & tested as components of PerkinElmer’s biobanking workflow.
VICTOR Nivo™ Multimode Plate Reader
For nucleic acid quantitation, the VICTOR Nivo™ multimode plate reader uses either UV-absorption at 260 nm and 260:280 nm ratios or the measurement of fluorescence intensity of a dye binding to double-stranded DNA (Qubit® assay kit, Thermo Fisher® Scientific) in 96- and 384-well microplate formats.
Modular & Scalable Automation
PerkinElmer’s automation solutions allow biorepositories to standardize procedures and implement best practices ensuring sample integrity and security, increasing throughput, and decreasing costs. PerkinElmer’s flexible instrumentation modules offer flexibility in throughput, capacity and dynamic volume range, high quality manufacturing standards, and outstanding customer service and support.
Increasing Throughput & Sample Security
PerkinElmer offers modular, scalable solutions addressing sample security requirements and changing throughput and workflow requirements to automate entire biobanking workflows.
Fast, Cost-effective Nucleic Acid Extraction from Flexible Input Volumes
With flexibility in throughput, capacity, and sample type, high quality manufacturing standards, and outstanding customer support, PerkinElmer’s chemagic™ nucleic acid extraction automation solutions process sample volumes ranging from 10 µL to 10 mL cost effectively and quickly.
Single Source Integration
PerkinElmer’s explorer™ G3 workstations seamlessly integrate many of the critical biobanking processes across platforms. With integrated nucleic acid isolation, sample assessment and a modular approach for increasing throughput, a tailored explorer™ G3 workstation can be designed to align with any analytical pipeline inputs.
CUSTOM explorer™ G3 WORKSTATION
Walk-away, seamless automation of nucleic acid extraction and preparation for analytical processing.
Sample Process Traceability
Improved Reproducibility & Accuracy
Automation eliminates most human handling steps, which are a primary source of run-to-run variation. PerkinElmer’s automated solutions improve reproducibility and accuracy by eliminating errors including mislabeling or misplacing samples.
PerkinElmer’s biobanking solutions facilitate sample tracking by incorporating automated barcode scanning into every step of sample processing. Samples are received by a biobank and placed into a PerkinElmer automation solution, where they are scanned by the barcode reader which communicates with the Laboratory Information Management Systems (LIMS) and processed according to predefined work orders.
Laboratory Information Management Systems (LIMS) are necessary for biobanks which need to manage a diverse array of samples, integrate with electronic medical and health records and comply with relevant regulatory environments such as HTA, GCLP, MHRA, FDA 21 CFR Part 11. Compatible with all major LIMS, PerkinElmer’s automation solutions allow biobanks to easily import data into management systems.
Primary Sample Scanned-in
- Register Rack ID & individual 2D elution tube barcodes
- Samples & reagents transferred to extraction plate
- Nucleic acid extraction
- Eluates transferred to 2D tubes (optional)
- 2D tube ID assigned in sample registry (optional)
- Print sample ID corresponding to rack & elution tube ID
For research use only. Not for use in diagnostic procedures.