JANUS G3 BioTX Pro Workstations2018-11-15T01:24:48+00:00

AUTOMATED LIQUID HANDLING PLATFORM FOR SMALL-SCALE PROTEIN PURIFICATION APPLICATIONS

JANUS® G3 BioTX Pro Workstations

  • Pre-programmed methods
  • Whole and partial plate workflows
  • Automated plate::shuttle module for fraction collection with user-defined volumes
  • Fully integrated vacuum filtration system for plate based purification and fraction collection

The JANUS® G3 BioTx Pro workstations enable consistent small scale protein purification and sample prep for analytical protein characterization required to support quality by design experimentation in both upstream and downstream processes. The JANUS BioTx Pro workstations are intuitive, flexible, automated instruments capable of performing parallel small-scale analytical protein purification. A graphical user interface accommodates a variety of screening experiments designed to determine the optimal conditions for purification of biotherapeutic proteins using small-scale, commercially available ion exchange and affinity chromatography solutions. With just one instrument, you can achieve rapid analysis of a range of sample volumes and concentrations to support Quality by Design experimentation in both upstream and downstream processes:

  • Expression optimization
  • Cell line selection
  • Purification process development
  • Bioanalytical sample prep

The JANUS BioTx Pro workstations are compatible with the following modes of purification:

  • Nexus PhyTips® columns
  • Atoll® RoboColumn® products
  • MediaScout® MiniChrom columns
  • GraviTrap® Columns
  • Resin-filled microtiter vacuum filtration plates

The Zephyr G3 NGS workstation produces sequence-ready samples with improved reproducibility and consistency while minimizing the labor-intensive steps associated with manual NGS sample preparation. With a walk-away solution and flexible sample processing (8 to 96 samples), the Zephyr G3 NGS workstation is an ideal solution for medium throughput labs enabling the parallel processing of 96 samples in less than eight hours.

The JANUS BioTx Pro workstations are compatible with the following modes of purification:

JANUS G3 BioTx Pro Workstation:

  • 12 deck positions
  • Compact footprint
  • Flexible control software and wizard driven application assistant
  • Automated fraction collection station with housing for up to 96 small scale columns

JANUS G3 BioTx Pro Plus Workstation:

  • 24 deck locations
  • MDT 96 tip head for parallel purification methods
  • Integrated gripper for labware positioning
  • Integrated vacuum manifold
Dimensions
JANUS® G3 Workstations Without an Enclosure
PlatformJANUS G3 BioTx Pro WorkstationJANUS G3 BioTx Pro Plus Workstation
Varispan 8-tipH: 864 mm | 34 in
W: 788 mm | 31 in
D: 838 mm | 33 in
N/A
Varispan + MDTN/AH: 1118 mm | 44 in
W: 1499 mm | 59 in
D: 838 mm | 33 in
(Includes space requirements for plate::shuttle)
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For research use only. Not for use in diagnostic procedures.

Precision Automated Pipetting with a Wide Dynamic Volume Range:

Pipetting ArmVolume% CVTip/HeadCondition
Varispan5 µL< 2%20 µL disposable tipDistilled water, 500 µL syringe
50 µL< 1%Fixed tipDistilled water, 500 µL syringe
MDT1 µL< 2%I20 disposable tip on I50 96-tip Head1 µL
1 µL< 5%I50 disposable tips on I50 96-tip Head1 µL
5 µL< 1%I235 disposable tips on I235 96-tip Head5 µL
50 µL< 1%I235 disposable tips on I235 96-tip Head50 µL
Microplate Deck Capacity:
JANUS G3 PlatformJANUS® G3 BioTx Pro Workstation ConfigurationJANUS® G3 BioTx Pro Plus Workstation Configuration
Varispan9 platesN/A
Varispan + MDTN/A20 plates
Dimensions:
Dimensions
JANUS® G3 Workstations Without an Enclosure
PlatformJANUS G3 BioTx Pro WorkstationJANUS G3 BioTx Pro Plus Workstation
Varispan 8-tipH: 864 mm | 34 in
W: 788 mm | 31 in
D: 838 mm | 33 in
N/A
Varispan + MDTN/AH: 1118 mm | 44 in
W: 1499 mm | 59 in
D: 838 mm | 33 in
(Includes space requirements for plate::shuttle)

Publications that Cite Using the JANUS® G3 BioTX™ Pro Workstations for Protein Purification

Gengenbach, B., Müschen, C., & Buyel, J. (2018). Expression and purification of human phosphatase and actin regulator 1 (PHACTR1) in plant-based systems. Protein Expression and Purification, 151, 46-55. doi:10.1016/j.pep.2018.06.003

van der Veen, A. G.,  Maillard, P. V., …,  Snijders, A. P. (2018). The RIG‐I‐like receptor LGP2 inhibits Dicer‐dependent processing of long double‐stranded RNA and blocks RNA interference in mammalian cells. EMBO, 37(12). Doi:10.15252/embj.201797479.