Sample preparation and characterization of proteins for quality by design (QbD) studies are important parts of process development; however, these studies, including design of experiments(DoE), can be time consuming and sample analysis can easily exceed the capacity of most labs.
Protein characterization involves both upstream protein purification optimization, as well as the downstream characterization of its purity, structure and function. Miniaturization of small-scale protein purification provides greater process optimization with larger QbD and DOE studies allowing for parallel processing of samples for increased statistical significance and greater breadth of variables within experimental shorter time frames.
PerkinElmer is committed to accelerating this process to help life science researchers make critical decisions earlier in the protein development workflow. Researchers can now screen for optimal protein characteristics earlier in the process, integrating Quality by Design initiatives into their protein therapeutic development workflow.